• DOI:10.1080/10915810701583010
Corpus ID: 41230661

Pharmaceutical Agents Known to Produce Disulfiram-Like Reaction: Effects on Hepatic Ethanol Metabolism and Brain Monoamines

@article{Karamanakos2007PharmaceuticalAK,
  title={Pharmaceutical Agents Known to Produce Disulfiram-Like Reaction: Effects on Hepatic Ethanol Metabolism and Brain Monoamines},
  author={P. Karamanakos and P. Pappas and V. Boumba and C. Thomas and M. Malamas and T. Vougiouklakis and M. Marselos},
  journal={International Journal of Toxicology},
  year={2007},
  volume={26},
  pages={423 - 432}
}

• P. Karamanakos, P. Pappas, +4 authors M. Marselos
• Published 2007
• Chemistry, Medicine
• International Journal of Toxicology

Several pharmaceutical agents produce ethanol intolerance, which is often depicted as disulfiram-like reaction. As in the case with disulfiram, the underlying mechanism is believed to be the accumulation of acetaldehyde in the blood, due to inhibition of the hepatic aldehyde dehydrogenases. In the present study, chloramphenicol, furazolidone, metronidazole, and quinacrine, which are reported to produce a disulfiram-like reaction, as well as disulfiram, were administered to Wistar rats and the… Expand

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