A Promising Approach Of Colon Targeted Drug Delivery System. International Journal of Pharmaceutical Research and Bio-science
- B Patel R
- Dolar et al. / Pharma Science Monitor
Oral administration of different dosage forms is the most common form of administration due to greater patient compliance and flexibility. Targeted drug delivery system is the system in which the dosage form is modified to deliver the drug at the target region or at the disease region. Targeted delivery to the colon is being explored not only for local colonic pathologies, but also for systemic delivery of drugs like proteins and peptides. There are several approaches use for targeted drug delivery for colon such as pH and time dependant, Microbial triggered, Pulsin cap and Port system. In which pulsing cap system the formulations develop in a capsule form. The plug placed in the capsule controls the release of drug. These kinds of formulations are used for the treatment of disorders of the large intestine (colon), such as Colon cancer, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) i.e. ulcerative colitis and Crohn’s disease. This is also a potential site for the treatment of diseases sensitive to circadian rhythms such as asthma, angina, hypertension and arthritis. This targeting of drug to the disease site lowers the requirement of higher doses of drug and thus reducing the dosage frequency and cost of the drugs, which ultimately leads to patients compliance.