Pharmañopo—Psychonautics: Human Intranasal, Sublingual, Intrarectal, Pulmonary and Oral Pharmacology of Bufotenine

@article{Ott2001PharmaopoPsychonauticsHI,
  title={Pharma{\~n}opo—Psychonautics: Human Intranasal, Sublingual, Intrarectal, Pulmonary and Oral Pharmacology of Bufotenine},
  author={Jonathan Ott},
  journal={Journal of Psychoactive Drugs},
  year={2001},
  volume={33},
  pages={273 - 281}
}
  • J. Ott
  • Published 1 July 2001
  • Biology
  • Journal of Psychoactive Drugs
Abstract Summarized are psychonautic bioassays (human self-experiments) of pharmañopo—crystalline bufotenine (5-HO-DMT; 5-hydroxy-N,N-dimethyltryptamine; dimethylserotonine), at times combined with harmaline or harmine—via intranasal, sublingual, intrarectal, pulmonary (inhaled vapor) and oral routes. This is done by way of pharmacological modeling of diverse South American shamanic inebriants, principally the snuffs ñopolyopo and cebíhatáj, prepared from seeds of Anadenanthera peregrina var… 

Pharmepéna-Psychonautics: Human Intranasal, Sublingual and Oral Pharmacology of 5-Methoxy-N, N-Dimethyl-Tryptamine

  • J. Ott
  • Psychology
    Journal of psychoactive drugs
  • 2001
Abstract Summarized are psychonautic bioassays (human self-experiments) of pharmepéna—crystalline 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT; O-Me-bufotenine), at times combined with crystalline

The hallucinogenic world of tryptamines: an updated review

TLDR
A comprehensive update on tryptamine hallucinogens, concerning their historical background, prevalence, patterns of use and legal status, chemistry, toxicokinetics, toxicodynamics and their physiological and toxicological effects on animals and humans is provided.

Transformative Psychopharmacology: the Case of 5-Methoxy-N,N-Dimethyltryptamine

  • J. Hesselink
  • Psychology
    International Journal of Psychotherapy Practice and Research
  • 2019
TLDR
The pharmacological, the transformative psychopharmacology, the effects and adverse events of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) and its place in postmodern medicine is presented.

Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions.

5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many

Obviation of Opioid Withdrawal Syndrome by Concomitant Administration of Naltrexone in Microgram Doses: Two Psychonautic Bioassays

  • J. Ott
  • Medicine
    Journal of psychoactive drugs
  • 2006
TLDR
It was found that coadministration of naltrexone with codeine phosphate obviated the development of both tolerance and physical dependency over several months of four daily oral doses of 200 mg, allowing abrupt (“cold turkey”), asymptomatic and uneventful withdrawal.

Recreational Use, Analysis and Toxicity of Tryptamines

TLDR
Information from Internet and from published scientific literature, organized in the way proposed in this review, provides an effective tool for specialists facing the emerging NPS threat to public health and public security, including the personnel working in Emergency Department.

Biological Effects and Biodistribution of Bufotenine on Mice

TLDR
Results show that the effective dose, 0.63 mg/day, is safe to be administered in mice, since it did not cause significant effects on the animals' physiology and on the CNS, and higher doses were well tolerated.

References

SHOWING 1-10 OF 59 REFERENCES

Pharmepéna-Psychonautics: Human Intranasal, Sublingual and Oral Pharmacology of 5-Methoxy-N, N-Dimethyl-Tryptamine

  • J. Ott
  • Psychology
    Journal of psychoactive drugs
  • 2001
Abstract Summarized are psychonautic bioassays (human self-experiments) of pharmepéna—crystalline 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT; O-Me-bufotenine), at times combined with crystalline

Pharmahuasca: human pharmacology of oral DMT plus harmine.

  • J. Ott
  • Biology, Psychology
    Journal of psychoactive drugs
  • 1999
TLDR
The 1967 Holmstedt-Lindgren hypothesis of the ayahuasca effect--oral psychoactivity of DMT consequent to monoamine-oxidase (MAO) inhibition from simultaneous ingestion of beta-carbolines--has been confirmed by eight self-experimenters.

Yanomamo Hallucinogens: Anthropological, Botanical, and Chemical Findings

The Yanomamo Indians of southern Venezuela and northern Brazil employ hallucinogenic snuffs made from a wide variety of feral and domestic plants. Schultes (1967: 303) has recently suggested that

Bufotenine esters.

TLDR
It was found that these esters all possess a relatively high affinity for the serotonin receptors of the isolated rat stomach fundus preparation, suggesting extensive hydrolysis of the esters to bufotenine does not occur under the conditions of the affinity assay.

Bufo toads and bufotenine: fact and fiction surrounding an alleged psychedelic.

TLDR
The extensive literature surrounding the Bufo toad and bufotenine is examined, and many of the myths and the misinformation that continue to vex both science and popular reporting are untangled.

Indole Alkaloids of Acer saccharinum (the Silver Maple), Dictyoloma incanescens, Piptadenia colubrina, and Mimosa hostilis

Several plants which we have studied recently have, by coincidence, yielded indole alkaloids of simple structure. Four of these are described in the present paper. Although numerous members of the

Effect of some indolealkylamines on man.

Throughout an arc described by the islands of the Caribbean, the shores of the Amazon, and as far as the western ridges of the Andes, in Colombia and Peru, there has been used since pre-Columbian
...