Phantom limb pain: a case of maladaptive CNS plasticity?

@article{Flor2006PhantomLP,
  title={Phantom limb pain: a case of maladaptive CNS plasticity?},
  author={Herta Flor and Lone Nikolajsen and Troels Staehelin Jensen},
  journal={Nature Reviews Neuroscience},
  year={2006},
  volume={7},
  pages={873-881}
}
Phantom pain refers to pain in a body part that has been amputated or deafferented. It has often been viewed as a type of mental disorder or has been assumed to stem from pathological alterations in the region of the amputation stump. In the past decade, evidence has accumulated that phantom pain might be a phenomenon of the CNS that is related to plastic changes at several levels of the neuraxis and especially the cortex. Here, we discuss the evidence for putative pathophysiological mechanisms… Expand

Paper Mentions

Interventional Clinical Trial
SPECIFIC AIMS Pain in both youth and adults is a complex, subjective and personal experience, and remains poorly understood. One particularly perplexing dimension of some forms… Expand
ConditionsAmplified Musculoskeletal Pain Syndrome (AMPS), Chronic Widespread Pain, Complex Regional Pain Syndrome (CRPS), (+3 more)
InterventionBehavioral
Interventional Clinical Trial
This study evaluates the effect of additional transcranial direct stimulation (tDCS) on pain in patients with chronic neuropathic pain undergoing treatment with regional… Expand
ConditionsNeuralgia, Neuropathic Pain
InterventionDevice
Blog Post
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  • 2008
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Behavioral interventions, stimulation, feedback, feedback and pharmacological interventions that are designed to reverse these maladaptive memory traces and enhance extinction may be beneficial for the treatment and prevention of phantom limb pain. Expand
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The EU consortium ‘EPIONE’ will challenge the status-quo of PLP treatment by actively creating natural, meaningful sensations that will restore the neuroplastic changes in the cortex and thereby control and alleviate pain. Expand
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The findings suggest multilevel neuroplasticity primarily located in the peripheral nerves, spinal cord and/or thalamocortical networks, indicating the need for diverse methods of treatment. Expand
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In major cases after amputation, patients are reported to have painful sensation in missing limbs, what is known as phantom limb pain (PLP). Since the first record of PLP hundred years ago, thoroughExpand
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The pathophysiology of phantom limb pain is complex and includes changes in the peripheral nerve, the dorsal root ganglia, spinal cord and cerebral cortex, and just a few treatments have good quality studies to support its use. Expand
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Phantom pain is a frequent sequel of the amputation of a limb or another body part and must be differentiated from residual limb pain, postoperative pain, and other chronic pain problems such as backExpand
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An overview of the proposed mechanistic theories as well as an overview of various treatments for phantom limb pain are provided. Expand
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