Phallotoxins bind to actins

@article{Wieland1974PhallotoxinsBT,
  title={Phallotoxins bind to actins},
  author={Theodor Wieland and Vimala Govindan},
  journal={FEBS Letters},
  year={1974},
  volume={46}
}
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54 Citations
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54 Citations

Interaction of phallotoxins with actin.

  • T. Wieland
  • Biology, Chemistry
    Advances in enzyme regulation
  • 1976

Spectroscopic evidence for the interaction of phalloidin with actin

Interaction of actin with phalloidin: polymerization and stabilization of F-actin.

Trypsin protection of hepatocytes against phalloidin

The interpretation of the experimental data suggests that trypsin might induce conformational changes in the membrane structure which prevent or delay the first step of interaction between phalloidin and the membrane surface.

Modification of actins by phallotoxins

  • T. Wieland
  • Biology, Chemistry
    Naturwissenschaften
  • 2004
The structure of F-actin is stabilized to such an extent that it will be resistant to the depolymerizing action of 0.6M KI and of deoxyribonuclease I, to denaturation by heat (70 °° C), and to local ruptures caused by ultrasonication or by cytochalasin B.

Phalloidin counteracts the inhibitory effect of actin on deoxyribonuclease I

Structural Effects and Functional Implications of Phalloidin and Jasplakinolide Binding to Actin Filaments.

The phosphorylation of the major proteins of the human erythrocyte membrane.

  • L. Waxman
  • Biology, Chemistry
    Archives of biochemistry and biophysics
  • 1979

Structural effects and functional implications of phalloidin and jasplakinolide binding to actin filaments

It is shown in atomic detail that phalloidin, a mushroom toxin that is routinely used to stabilize and label actin filaments, suspends the structural changes in actin, likely influencing its interaction with actin binding proteins.

Total Synthesis of the Death Cap Toxin Phalloidin: Atropoisomer Selectivity Explained by Molecular-Dynamics Simulations.

The enantioselective synthesis of the key amino acid (2S,4R)-4,5-dihydroxy-leucine is reported as a basis for the first total synthesis of phalloidin, which was accomplished by two different synthesis strategies.
...

References

SHOWING 1-4 OF 4 REFERENCES

Suche nach einem Metaboliten bei Vergiftung mit Desmethylphalloin (DMP)

It can be concluded that [3H]desmethylphalloin and most probably also phalloidine are not metabolized in the livers of rats and mice.

Relation of toxicity and conformation of phallotoxins as revealed by optical rotatory dispersion studies.

Stability of the “aqueous” conformation in a lipophilic environment is apparently the second prerequisite for a toxic action of phallopeptides.

Interaction of Actin and Myosin in the Absence and Presence of ATP

  • P. DanckerM. Hoffmann
  • Biology, Chemistry
    Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
  • 1973
The activation of myosin ATPase by act in-tropomyosin-troponin is reduced after tryptic digestion of actin- Troponin, which affects, according to SDS gel electro phoresis, mainly two components of troponin with molecular weights of about 32 000 and 25 000, respectively.

Über die Inhaltsstoffe des grünen Knollenblätterpilzes, XXXIV1) Amanin und die Amanitine sind Sulfoxide

Aus UV-spektroskopischen Vergleichen mit zwei durch H2O2-Oxydation von Phalloidin erhaltenen Sulfoxiden (1b und 1c) und mit Skatyl-(2)-athyl-sulfoxid (2b) folgt die Sulfoxid-Natur des Amanins (7e).…