Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner.

@article{Rybicka2012PhagosomalPI,
  title={Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner.},
  author={Joanna M Rybicka and Dale R Balce and Sibapriya Chaudhuri and Euan Ramsay Orr Allan and Robin M Yates},
  journal={The EMBO journal},
  year={2012},
  volume={31 4},
  pages={932-44}
}
The level of proteolysis within phagosomes of dendritic cells (DCs) is thought to be tightly regulated, as it directly impacts the cell's efficiency to process antigen. Activity of the antimicrobial effector NADPH oxidase (NOX2) has been shown to reduce levels of proteolysis within phagosomes of both macrophages and DCs. However, the proposed mechanisms underlying these observations in these two myeloid cell lineages are dissimilar. Using real-time analysis of lumenal microenvironmental… CONTINUE READING

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