Phagosomal acidification in Paramecium: effects on lysosomal fusion.

  title={Phagosomal acidification in Paramecium: effects on lysosomal fusion.},
  author={A. K. K. Fok and Masaki Ueno and E A Azada and Richard D M Allen},
  journal={European journal of cell biology},
  volume={43 3},
Phagosomes of paramecia and amoeba and endosomes of fibroblasts and other mammalian cells are acidified prior to lysosomal fusion. The question, whether the phagosomal acidification process in paramecia is required for phagosome-lysosome fusion, was studied using ionophores, weak bases, and cytochalasin B (CB) in combination with monoclonal antibodies, acid phosphatase (AcPase) cytochemistry, and lysosome morphometry. Digestive vacuoles (DVs) of known ages were treated and examined. In… CONTINUE READING

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