Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implications.

@article{Magnus2002PhagocytoticRO,
  title={Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implications.},
  author={Tim Magnus and Andrew Chan and John Savill and Klaus Victor Toyka and Ralf Gold},
  journal={Journal of neuroimmunology},
  year={2002},
  volume={130 1-2},
  pages={1-9}
}
Apoptotic cell death of inflammatory T cells is an established mechanism to terminate an autoimmune inflammatory response in the rodent and human central nervous system (CNS). The efficient clearance of apoptotic cells protects the tissue from leakage of potentially harmful substances from secondary necrotic cells. As the resident phagocyte, the microglial cell is the primary candidate for the clearance of apoptotic lymphocytes. Furthermore, the phagocytosis of apoptotic cells is accompanied by… CONTINUE READING

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