Phagocytosis of viable Candida albicans by alveolar macrophages: lack of opsonin function of surfactant protein A.

@article{Rosseau1997PhagocytosisOV,
  title={Phagocytosis of viable Candida albicans by alveolar macrophages: lack of opsonin function of surfactant protein A.},
  author={Simone Rosseau and Annett Guenther and Werner Seeger and Juergen Lohmeyer},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={175 2},
  pages={421-8}
}
Surfactant protein A (SP-A) contributes to host defense by opsonizing microbial organisms for phagocytosis by alveolar macrophages (AM). The role of SP-A as opsonin for phagocytosis of Candida albicans was analyzed. AM in suspension exhibited no phagocytosis of nonopsonized yeast. This was not increased by SP-A, whether provided for preincubation of AM or yeast or present during coincubation. However, the engulfment of serum-opsonized yeast by AM in suspension was inhibited by SP-A. This… CONTINUE READING