Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony-stimulating factor

@article{Munn1990PhagocytosisOT,
  title={Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony-stimulating factor},
  author={David H. Munn and Norman Kin Wai Cheung},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={172},
  pages={231 - 237}
}
Macrophages and cultured human monocytes can mediate efficient antibody-dependent cytotoxicity (ADCC) against human tumor cells using monoclonal antibodies (mAbs). The mechanism of this killing is usually assumed to involve secreted factors (reactive oxygen intermediates, tumor necrosis factor, or other cytotoxic factors) leading to target cell lysis. In this study, we present evidence that phagocytosis of intact target cells is the principal mechanism of antitumor cytotoxicity in our in vitro… CONTINUE READING