Phagocytosis of picornavirus-infected cells induces an RNA-dependent antiviral state in human dendritic cells.

@article{Kramer2008PhagocytosisOP,
  title={Phagocytosis of picornavirus-infected cells induces an RNA-dependent antiviral state in human dendritic cells.},
  author={Matthijs Kramer and Barbara M. Schulte and Liza W J Toonen and Paola M Barral and Paul B Fisher and Kjerstin H. W. Lanke and Jochem M. D. Galama and Frank J M van Kuppeveld and Gosse J Adema},
  journal={Journal of virology},
  year={2008},
  volume={82 6},
  pages={2930-7}
}
Dendritic cells (DCs) play a central role in instructing antiviral immune responses. DCs, however, can become targeted by different viruses themselves. We recently demonstrated that human DCs can be productively infected with echoviruses (EVs), but not coxsackie B viruses (CVBs), both of which are RNA viruses belonging to the Enterovirus genus of the Picornaviridae family. We now show that phagocytosis of CVB-infected, type I interferon-deficient cells induces an antiviral state in human DCs… CONTINUE READING

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