Phagocytosis of photoreceptor outer segments by transplanted human neural stem cells as a neuroprotective mechanism in retinal degeneration.

@article{Cuenca2013PhagocytosisOP,
  title={Phagocytosis of photoreceptor outer segments by transplanted human neural stem cells as a neuroprotective mechanism in retinal degeneration.},
  author={Nicol{\'a}s Cuenca and Laura Fern{\'a}ndez-S{\'a}nchez and Trevor J. McGill and Bin Lu and Shaomei Wang and Raymond Lund and Stephen L Huhn and Alexandra Capela},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 10},
  pages={6745-56}
}
PURPOSE Transplantation of human central nervous system stem cells (HuCNS-SC) into the subretinal space of Royal College of Surgeons (RCS) rats preserves photoreceptors and visual function. To explore possible mechanism(s) of action underlying this neuroprotective effect, we performed a detailed morphologic and ultrastructure analysis of HuCNS-SC transplanted retinas. METHODS The HuCNS-SC were transplanted into the subretinal space of RCS rats. Histologic examination of the transplanted… CONTINUE READING
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Photoreceptor rescue. Eye (Lond). 1998;12:591–596

  • PJ Luthert, NH Chong
  • IOVS j October 2013 j Vol. 54 j No
  • 2013
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