Phagocytosis of mast cell granules by cultured fibroblasts.

  title={Phagocytosis of mast cell granules by cultured fibroblasts.},
  author={Potluri V Subba Rao and Marc M. Friedman and Fred M Atkins and Dean D Metcalfe},
  journal={Journal of immunology},
  volume={130 1},
Cultured rat embryonic skin fibroblasts phagocytosed rat mast cell granules added to the medium or released from co-cultured mast cells by rabbit anti-rat IgE or Compound 48/80. Electron microscopy of fibroblasts incubated with mast cell granules revealed that granules adjacent to the plasmalemma were engulfed by long, thin cytoplasmic processes. Internalization proceeded to fusion of encircling processes and formation of phagosomes. Microtubules and 60 A microfilaments became closely… CONTINUE READING
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