Phagocytosis of Apoptotic Cells Is Regulated by a UNC-73/TRIO-MIG-2/RhoG Signaling Module and Armadillo Repeats of CED-12/ELMO

@article{Debakker2004PhagocytosisOA,
  title={Phagocytosis of Apoptotic Cells Is Regulated by a UNC-73/TRIO-MIG-2/RhoG Signaling Module and Armadillo Repeats of CED-12/ELMO},
  author={C Debakker and Lisa B. Haney and Jason Michael Kinchen and Cynthia M. Grimsley and Mingjian Lu and Doris Klingele and Pei-Ken Hsu and Bin-Kuan Chou and Li-Chun Cheng and Anne Blangy and John Sondek and Michael O. Hengartner and Yi-Chun Wu and Kodi S. Ravichandran},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={2208-2216}
}

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Evidence is presented for a physical link between CED-1 or CD91/LRP and the adapter protein C ED-6/GULP during engulfment of apoptotic cells and further elucidate the pathway suggested by the genetic studies.
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It is proposed that CED-2/CrkII and Ced-5/DOCK180 function to activate CED -10/Rac in a GTPase signalling pathway that controls the polarized extension of cell surfaces.
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This finding suggests that Rac activation by the ELMO·Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 rather than generalized Rac activation plays a role in cell migration.
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