Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis

@inproceedings{Lvque2018PhagocytosisDO,
  title={Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis},
  author={Manuella L{\'e}v{\^e}que and Aubin Penna and Sophie Le Trionnaire and Chantal Belleguic and Beno{\^i}t Desrues and Graziella Brinchault and St{\'e}phane Jouneau and Dominique Lagadic-Gossmann and Corinne A E Martin-Chouly},
  booktitle={Scientific Reports},
  year={2018}
}
Whereas many phagocytosis steps involve ionic fluxes, the underlying ion channels remain poorly defined. As reported in mice, the calcium conducting TRPV2 channel impacts the phagocytic process. Macrophage phagocytosis is critical for defense against pathogens. In cystic fibrosis (CF), macrophages have lost their capacity to act as suppressor cells and thus play a significant role in the initiating stages leading to chronic inflammation/infection. In a previous study, we demonstrated that… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 54 references

The impact of impaired macrophage functions in cystic fibrosis disease progression

  • M. Lévêque, S. Le Trionnaire, P. Del Porto, C. Martin-Chouly
  • J. Cyst. Fibros
  • 2016

Evidence for the role of lipid rafts and sphingomyelin in Ca 2 + - gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals

  • É. Sághy
  • Pharmacol . Res .
  • 2015

Evidence for the role of lipid rafts and sphingomyelin in Ca2 + -gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve

  • É Sághy
  • terminals. Pharmacol. Res
  • 2015

Similar Papers

Loading similar papers…