Phagocytosis by retinal pigment epithelium: evaluation of modulating agents with an organ culture model.

@article{Goldhar1984PhagocytosisBR,
  title={Phagocytosis by retinal pigment epithelium: evaluation of modulating agents with an organ culture model.},
  author={S W Goldhar and P. K. Basu and Narendranath S. Ranadive},
  journal={Canadian journal of ophthalmology. Journal canadien d'ophtalmologie},
  year={1984},
  volume={19 1},
  pages={33-5}
}
Several drugs known to modulate the phagocytic activity of "professional" phagocytes were examined for effects on the bovine retinal pigment epithelium (RPE). The test system employed was an organ culture model (the RPE cup) developed previously. Iodoacetate depressed the ability of the RPE to phagocytose latex particles labelled with iodine 125, as measured by the gamma-emissions from the RPE cup. Indomethacin, sodium salicylate, azathioprine and alcohol also showed depressant effects… CONTINUE READING