Phagocytosis and antimicrobicidal activity of polymorphonuclear leucocytes against gentamicin-sensitive and resistant strains of Pseudomonas aeruginosa.

Abstract

The ability of human polymorphonuclear leucocytes (PMNs) to ingest and kill gentamicin-sensitive and resistant Pseudomonas aeruginosa strains was studied. Strains becoming resistant to gentamicin either by laboratory training or through an R-factor were more susceptible to the phagocytic and bactericidal function of the PMNs. These results may explain previous clinical and laboratory observations indicating that gentamicin-resistant strains are less virulent.

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@article{Lianou1983PhagocytosisAA, title={Phagocytosis and antimicrobicidal activity of polymorphonuclear leucocytes against gentamicin-sensitive and resistant strains of Pseudomonas aeruginosa.}, author={P E Lianou and H P Bassaris and C S Papadimitriou and N J Legakis and J T Papavassiliou}, journal={The Journal of infection}, year={1983}, volume={7 1}, pages={46-50} }