Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells.

@article{Tate1995PhagocytosisAH,
  title={Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells.},
  author={David J. Tate and Michael V. Miceli and David A. Newsome},
  journal={Investigative ophthalmology & visual science},
  year={1995},
  volume={36 7},
  pages={1271-9}
}
PURPOSE Reactive oxygen intermediates have been implicated in the aging process and degenerative diseases of the eye, including retinopathy of prematurity, cataractogenesis, and macular degeneration. The purpose of this study was to investigate the effect of phagocytosis of photoreceptor outer segments and the addition of exogenous H2O2 on catalase and metallothionein expression in human retinal pigment epithelial cells. METHODS Confluent RPE cells were treated with bovine photoreceptor outer… CONTINUE READING
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