Phagocytic entry of Legionella pneumophila into macrophages through phosphatidylinositol 3,4,5-trisphosphate-independent pathway.

@article{Harada2012PhagocyticEO,
  title={Phagocytic entry of Legionella pneumophila into macrophages through phosphatidylinositol 3,4,5-trisphosphate-independent pathway.},
  author={Toshihiko Harada and Takashi Tanikawa and Yasunori Iwasaki and Masao Yamada and Yasuyuki Imai and Masaki Miyake},
  journal={Biological & pharmaceutical bulletin},
  year={2012},
  volume={35 9},
  pages={1460-8}
}
Legionella pneumophila, a causative agent of Legionnaire's disease, is an intracellular pathogen. It intervenes in the signal transduction of macrophages by secreting effector molecules through the Icm/Dot type IV secretion system (T4SS). There is a connection between signaling cascades that regulate phagocytosis and the production of reactive oxygen species (ROS). Class I phosphatidylinositol 3-kinase (PI3-K) and its product phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) play key roles… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Phosphoinositide lipids and the Legionella pathogen vacuole.

Current topics in microbiology and immunology • 2013
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Similar Papers

Loading similar papers…