Phagocytic cells metabolize 25-hydroxyvitamin D3 in vitro.

  title={Phagocytic cells metabolize 25-hydroxyvitamin D3 in vitro.},
  author={Myron S. Cohen and Terence K. Gray},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={81 3},
Phagocytic cells are widely distributed in tissues known to be important in the metabolism of vitamin D. Incubation of human polymorphonuclear leukocytes and monocytes and resident rat peritoneal macrophages with 3H-labeled 25-hydroxyvitamin D3 leads to the formation of three radioactive peaks. Peak I is most consistent with a lactone derivative of 25-hydroxyvitamin D3, and peak II has been identified as putative 24,25-dihydroxyvitamin D3. Peak III is a novel metabolite of 25-hydroxyvitamin D3… CONTINUE READING