Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammation.

  title={Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammation.},
  author={Dirk Foell and Michael Frosch and Clemens Sorg and Johannes Roth},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={344 1-2},
The EF-hand homolog family of S100 proteins comprises the largest group of calcium-binding proteins. Within this S100 family, the phagocyte-specific calcium-binding proteins are pro-inflammatory molecules expressed and secreted by phagocytes, which play a pivotal role within the innate immune system. Although the exact biological functions of these proteins still remain to be defined in greater detail, there is evidence that they are involved in a pro-inflammatory axis associated with various… CONTINUE READING
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