Phagocyte-derived reactive species: salvation or suicide?

  title={Phagocyte-derived reactive species: salvation or suicide?},
  author={Barry Halliwell},
  journal={Trends in biochemical sciences},
  volume={31 9},
Activated phagocytes produce "reactive oxygen, halogen and nitrogen species" that help to kill some types of microorganism. How these species destroy microorganisms remains, however, an enigma: both direct oxidative damage and indirect damage (whereby reactive species promote the actions of other antibacterial agents) are involved, and no single mechanism is likely to account for the killing of all microorganisms. Phagocyte-derived reactive species are known to injure human tissues and to… CONTINUE READING