Phages from landscape libraries as substitute antibodies.

@article{Petrenko2000PhagesFL,
  title={Phages from landscape libraries as substitute antibodies.},
  author={Valery A. Petrenko and G. P. Smith},
  journal={Protein engineering},
  year={2000},
  volume={13 8},
  pages={589-92}
}
In 'landscape' phage, as in traditional phage-display constructs, foreign peptides or proteins are fused to coat proteins on the surface of a filamentous phage particle. Unlike conventional constructs, however, each virion displays thousands of copies of the peptide in a repeating pattern, subtending a major fraction of the viral surface. The phage body serves as an interacting scaffold to constrain the peptide into a particular conformation, creating a defined organic surface structure… CONTINUE READING

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