Phages build themselves a wall.


Designing proteins with cavities In de novo protein design, creating custom-tailored binding sites is a particular challenge because these sites often involve nonideal backbone structures. For example, curved b sheets are a common ligand binding motif. Marcos et al. investigated the principles that drive b-sheet curvature by studying the geometry of b sheets in natural proteins and folding simulations. In a step toward custom design of enzyme catalysts, they used these principles to control b-sheet geometry and design proteins with differently shaped cavities. —VV

DOI: 10.1126/science.355.6321.143-f

Cite this paper

@article{Hurtley2017PhagesBT, title={Phages build themselves a wall.}, author={Stella M Hurtley}, journal={Science}, year={2017}, volume={355 6321}, pages={143-144} }