Phage treatment of an aortic graft infected with Pseudomonas aeruginosa

@inproceedings{Chan2018PhageTO,
  title={Phage treatment of an aortic graft infected with Pseudomonas aeruginosa},
  author={Benjamin K. Chan and Paul E Turner and Samuel S. Kim and Hamid R. Mojibian and John A. Elefteriades and Deepak Narayan},
  booktitle={Evolution, medicine, and public health},
  year={2018}
}
Management of prosthetic vascular graft infections caused by Pseudomonas aeruginosa can be a significant challenge to clinicians. These infections often do not resolve with antibiotic therapy alone due to antibiotic resistance/tolerance by bacteria, poor ability of antibiotics to permeate/reduce biofilms and/or other factors. Bacteriophage OMKO1 binding to efflux pump proteins in P. aeruginosa was consistent with an evolutionary trade-off: wildtype bacteria were killed by phage whereas… CONTINUE READING