Phage therapy in clinical practice: treatment of human infections.

  title={Phage therapy in clinical practice: treatment of human infections.},
  author={Elizabeth Kutter and Daniel De Vos and Guram Gvasalia and Zemphira Alavidze and Lasha Gogokhia and Sarah J Kuhl and Stephen T. Abedon},
  journal={Current pharmaceutical biotechnology},
  volume={11 1},
Phage therapy is the application of bacteria-specific viruses with the goal of reducing or eliminating pathogenic or nuisance bacteria. While phage therapy has become a broadly relevant technology, including veterinary, agricultural, and food microbiology applications, it is for the treatment or prevention of human infections that phage therapy first caught the world's imagination--see, especially, Arrowsmith by Sinclair Lewis (1925)--and which today is the primary motivator of the field… 

Safety and efficacy of phage therapy via the intravenous route.

It is argued that the large and continuing global health problems of typhoid and Staphylococcus aureus are exacerbated by the increasing antibiotic resistance of these pathogens, and are excellent candidates for use of IV phage therapy.

Phage Therapy: A Potential Alternative in the Treatment of Multi-Drug Resistant Bacterial Infections

Phage therapy was used to treat and prevent infectious bacterial diseases in the former Soviet Union and Eastern Europe and was abandoned by the West in the 1940s with antibiotic era springing up.

Phage Therapy

The past and current status of phage therapy is described and the most recent advances in this domain are presented.

Phage cocktails and the future of phage therapy.

This review considers phage therapy that can be used for treating bacterial infections in humans, domestic animals and even biocontrol in foods, and explores a regulatory framework for such an approach based on an influenza vaccine model.

Bacteriophage therapy against plant, animal and human pathogens

The current knowledge on phage therapy, its advantages and potential drawbacks are summarized and the application of phages against plant pathogens, especially Erwinia amylovora, and the current status of phage Therapy against food-borne, animal and human pathogens is presented.

Bacteriophages and their endolysins for control of pathogenic bacteria

This chapter presents an overview of phage-based approaches which have been employed for the elimination of pathogenic bacteria.

Pharmacologically Aware Phage Therapy: Pharmacodynamic and Pharmacokinetic Obstacles to Phage Antibacterial Action in Animal and Human Bodies

Greater awareness of what obstacles to this success generally or specifically can exist, as documented in this review, should aid in the further development of phage therapy toward wider use.

Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?

It is found that about half of 70 human phage treatment reports—published in English thus far in the 2000s—are suggestive of phage-mediated anti-bacterial infection efficacy, suggesting a valid utility in employing phages to treat otherwise difficult-to-cure bacterial infections.

Phage for Biocontrol

Egged phage-based bactericidal delivery vehicles will be introduced as a treatment approach for the biocontrol of a variety of important pathogens, suitable for concurrent treatment with standard antibiotics and possibly become a suitable replacement.

Phage therapy pharmacology phage cocktails.




Phage choice, isolation, and preparation for phage therapy.

The factors that determine the methods of isolation, analysis, and identification of phage species for phage therapy are discussed and the various methods available for purifying phages are discussed as well as considerations of the degree of purification which is sufficient for various applications.

Designing phage therapeutics.

Phages, both naturally occurring isolates or otherwise modified constructs, can be combined into cocktails which provide collectively enhanced capabilities such as expanded overall host range and thereby efficacy through informed design.

Phage therapy pharmacology.

It is found that phage therapy efficacy is highly dependent on attaining relatively high phage "killing titers", and that attainment of sufficient titers solely via in situ phage replication should, in some or many circumstances, not be counted upon.

Bacteriophage therapy in children: facts and prospects.

It can be concluded that the results of the therapeutic and prophylactic application of phages against multi-drug resistant pathogens are encouraging, and it seems clear that bacteriophages need further evaluation regarding the control of bacterial infection in children.

European regulatory conundrum of phage therapy.

The creation of a specific section for phage therapy under the Advanced Therapy Medicinal Product Regulation is suggested.

Bacteriophage therapy: experience from the Eliava Institute, Georgia

The increase in the incidence of multi-antibiotic-resistant bacteria and the absence of effective means for their control has led to increasing international interest in phage therapy and in the long experience of the Eliava Institute.

New insights into the possible role of bacteriophages in host defense and disease

If, indeed, phages can modify functions of β3+ cells (platelets, monocytes, lymphocytes, cancer cells) they could be important biological response modifiers regulating migration and activities of those cells.

Immunogenic effect of bacteriophage in patients subjected to phage therapy.

Fifty seven cases of bacterial infections subjected to phage therapy were tested for a production of antibodies against the applied bacteriophages. Monoinfections confirmed in 40 patients were caused

Bacterial viruses against viruses pathogenic for man?

Bacteriophage host range and bacterial resistance.