Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa

@inproceedings{Chan2016PhageSR,
  title={Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa},
  author={Benjamin K. Chan and Mark J. Sistrom and John E. Wertz and Kaitlyn E. Kortright and Deepak Narayan and Paul E Turner},
  booktitle={Scientific reports},
  year={2016}
}
Increasing prevalence and severity of multi-drug-resistant (MDR) bacterial infections has necessitated novel antibacterial strategies. Ideally, new approaches would target bacterial pathogens while exerting selection for reduced pathogenesis when these bacteria inevitably evolve resistance to therapeutic intervention. As an example of such a management strategy, we isolated a lytic bacteriophage, OMKO1, (family Myoviridae) of Pseudomonas aeruginosa that utilizes the outer membrane porin M (OprM… CONTINUE READING
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