Phage selection of photoswitchable peptide ligands.

  title={Phage selection of photoswitchable peptide ligands.},
  author={Silvia Bellotto and Shiyu Chen and Inmaculada Rentero Rebollo and Hermann A Wegner and Christian Heinis},
  journal={Journal of the American Chemical Society},
  volume={136 16},
Photoswitchable ligands are powerful tools to control biological processes at high spatial and temporal resolution. Unfortunately, such ligands exist only for a limited number of proteins and their development by rational design is not trivial. We have developed an in vitro evolution strategy to generate light-activatable peptide ligands to targets of choice. In brief, random peptides were encoded by phage display, chemically cyclized with an azobenzene linker, exposed to UV light to switch the… CONTINUE READING
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