Phage-mediated bioluminescent detection of Bacillus anthracis.

  title={Phage-mediated bioluminescent detection of Bacillus anthracis.},
  author={David A. Schofield and C. Gwyneth Cathyl - Bickford Westwater},
  journal={Journal of applied microbiology},
  volume={107 5},
AIMS Bacillus anthracis, the causative agent of anthrax, is a serious human pathogen. The aim of this study was to provide the proof of principle results for the development of a 'bioluminescent' reporter bacteriophage that was capable of specifically detecting B. anthracis. METHODS AND RESULTS The reporter phage was engineered by integrating the bacterial luxA and luxB reporter genes into a nonessential region of the lysogenic Wbeta phage genome. This resulted in a phage that was capable of… CONTINUE READING

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