Phage-mediated Selection and the Evolution and Maintenance of Restriction-modification.

  title={Phage-mediated Selection and the Evolution and Maintenance of Restriction-modification.},
  author={Ryszard Korona and Bruce R. Levin},
  journal={Evolution; international journal of organic evolution},
  volume={47 2},
Restriction-modification (R-M) was discovered because it provides bacteria with immunity to phage infection. But, is phage-mediated selection the sole mechanism responsible for the evolution and maintenance of these ubiquitous and multiply evolved systems? In an effort to answer this question, we have performed experiments with laboratory populations of E. coli and phage and computer simulations. We consider two ecological situations whereby phage-mediated selection could favor R-M immunity; i… CONTINUE READING
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