Phage-coded protein prevents restriction of unmodified progeny T4 DNA

HOST-controlled restriction modification systems usually prevent the survival of unmodified genomes in bacterial cells1–4. Phage DNA can be modified by methylation (λ, and f1)5–7 or by glucosylation (T-even phages3). Modification of the λ genome is mediated by a host methylase8 whereas modification of the T4 genome is by phage coded α- and β-glucosyl… CONTINUE READING