Phage Lambda CIII: A Protease Inhibitor Regulating the Lysis-Lysogeny Decision

@article{Kobiler2007PhageLC,
  title={Phage Lambda CIII: A Protease Inhibitor Regulating the Lysis-Lysogeny Decision},
  author={Oren Kobiler and Assaf Rokney and Amos B. Oppenheim},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={465 - 506}
}
The ATP-dependent protease FtsH (HflB) complexed with HflKC participates in post-translational control of the lysis-lysogeny decision of bacteriophage lambda by rapid degradation of lambda CII. Both phage-encoded proteins, the CII transcription activator and the CIII polypeptide, are required for efficient lysogenic response. The conserved CIII is both an inhibitor and substrate of FtsH. Here we show that the protease inhibitor CIII is present as oligomeric amphipathic alpha helical structures… CONTINUE READING

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A Genetic Switch: Phage Lambda Revisted: CSHL Press

  • M Ptashne
  • 2004
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