Phage Display–Mediated Discovery of Novel Tyrosinase-Targeting Tetrapeptide Inhibitors Reveals the Significance of N-Terminal Preference of Cysteine Residues and Their Functional Sulfur Atom s

Abstract

Tyrosinase, a key copper-containing enzyme involved in melanin biosynthesis, is closely associated with hyperpigmentation disorders, cancer, and neurodegenerative diseases, and as such, it is an essential target in medicine and cosmetics. Known tyrosinase inhibitors possess adverse side effects, and there are no safety regulations; therefore, it is… (More)

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@inproceedings{Lee2014PhageDD, title={Phage Display–Mediated Discovery of Novel Tyrosinase-Targeting Tetrapeptide Inhibitors Reveals the Significance of N-Terminal Preference of Cysteine Residues and Their Functional Sulfur Atom s}, author={Yu-Ching Lee and Nai-Wan Hsiao and Tien-Sheng Tseng and Wang-Chuan Chen and Hui-Hsiung Lin and Sy-Jye Leu and Ei-Wen Yang and Keng-Chang Tsai}, year={2014} }