Phage ϕ29 protein p1 promotes replication by associating with the FtsZ ring of the divisome in Bacillus subtilis

  title={Phage ϕ29 protein p1 promotes replication by associating with the FtsZ ring of the divisome in Bacillus subtilis},
  author={David Ballesteros-Plaza and Isabel Holguera and D. Scheffers and M. Salas and D. Mu{\~n}oz-Esp{\'i}n},
  journal={Proceedings of the National Academy of Sciences},
  pages={12313 - 12318}
  • David Ballesteros-Plaza, Isabel Holguera, +2 authors D. Muñoz-Espín
  • Published 2013
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • During evolution, viruses have optimized the interaction with host factors to increase the efficiency of fundamental processes such as DNA replication. Bacteriophage ϕ29 protein p1 is a membrane-associated protein that forms large protofilament sheets that resemble eukaryotic tubulin and bacterial filamenting temperature-sensitive mutant Z protein (FtsZ) polymers. In the absence of protein p1, phage ϕ29 DNA replication is impaired. Here we show that a functional fusion of protein p1 to YFP… CONTINUE READING
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