Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults.

  title={Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults.},
  author={Nitin Jain and Kathryn G. Roberts and Elias J Jabbour and Keyur Pravinchandra Patel and Agda Karina Eterovic and Ken Chung Chen and Patrick A. Zweidler-McKay and Xinyan Y Lu and Gloria Fawcett and S Alex Wang and Sergej N Konoplev and Richard C Harvey and I-Ming Chen and Debbie Payne-Turner and Marcus B. Valentine and Deborah A. Thomas and Guillermo Garcia-Manero and Farhad Ravandi and Jorge E. Cortes and Steven M. Kornblau and Susan O'brien and Sherry A. Pierce and Jeffrey L. Jorgensen and Kenna R. Mills Shaw and Cheryl L. Willman and Charles G Mullighan and Hagop M Kantarjian and Marina Y Konopleva},
  volume={129 5},
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph-like ALL in adults. Patients with newly diagnosed B-cell ALL (B-ALL) who received frontline chemotherapy at MD Anderson Cancer Center underwent gene expression profiling of leukemic cells. Of 148 patients, 33.1% had Ph-like, 31.1% had Ph+, and 35.8% had other B-ALL subtypes (B-other). Within the Ph-like ALL cohort, 61… CONTINUE READING
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