• Biology, Medicine
• Published in PLoS genetics 2016
• DOI:10.1371/journal.pgen.1006238

Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity

@inproceedings{McDonald2016Pfh1IA,
  title={Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity},
  author={Karin R. McDonald and Amanda J Guise and Parham Pourbozorgi-Langroudi and Ileana M. Cristea and Virginia A. Zakian and John A Capra and Nasim Sabouri},
  booktitle={PLoS genetics},
  year={2016}
}

• Karin R. McDonald, Amanda J Guise, +4 authors Nasim Sabouri

Replicative DNA helicases expose the two strands of the double helix to the replication apparatus, but accessory helicases are often needed to help forks move past naturally occurring hard-to-replicate sites, such as tightly bound proteins, RNA/DNA hybrids, and DNA secondary structures. Although the Schizosaccharomyces pombe 5'-to-3' DNA helicase Pfh1 is known to promote fork progression, its genomic targets, dynamics, and mechanisms of action are largely unknown. Here we address these… CONTINUE READING

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