Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity

@inproceedings{McDonald2016Pfh1IA,
  title={Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity},
  author={Karin R. McDonald and Amanda J Guise and Parham Pourbozorgi-Langroudi and Ileana M. Cristea and Virginia A. Zakian and John A Capra and Nasim Sabouri},
  booktitle={PLoS genetics},
  year={2016}
}
Replicative DNA helicases expose the two strands of the double helix to the replication apparatus, but accessory helicases are often needed to help forks move past naturally occurring hard-to-replicate sites, such as tightly bound proteins, RNA/DNA hybrids, and DNA secondary structures. Although the Schizosaccharomyces pombe 5'-to-3' DNA helicase Pfh1 is known to promote fork progression, its genomic targets, dynamics, and mechanisms of action are largely unknown. Here we address these… CONTINUE READING

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