Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins

  title={Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins},
  author={Alex Bateman and Ewan Birney and Richard Durbin and Sean R. Eddy and Robert D. Finn and Erik L. L. Sonnhammer},
  journal={Nucleic acids research},
  volume={27 1},
Pfam is a collection of multiple alignments and profile hidden Markov models of protein domain families. Release 3.1 is a major update of the Pfam database and contains 1313 families which are available on the World Wide Web in Europe at and, and in the US at Over 54% of proteins in SWISS-PROT-35 and SP-TrEMBL-5 match a Pfam family. The primary changes of Pfam since release 2.1 are that we now use the more… CONTINUE READING
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