PfPK7, an atypical MEK-related protein kinase, reflects the absence of classical three-component MAPK pathways in the human malaria parasite Plasmodium falciparum.

@article{Dorin2005PfPK7AA,
  title={PfPK7, an atypical MEK-related protein kinase, reflects the absence of classical three-component MAPK pathways in the human malaria parasite Plasmodium falciparum.},
  author={Dominique Dorin and Jean-Philippe Semblat and Patrick Poullet and Pietro Alano and J P Dean Goldring and Christina Whittle and Shelley Patterson and Debopam Chakrabarti and Christian D. Doerig},
  journal={Molecular microbiology},
  year={2005},
  volume={55 1},
  pages={184-96}
}
Two members of the mitogen-activated protein kinase (MAPK) family have been previously characterized in Plasmodium falciparum, but in vitro attempts at identifying MAP kinase kinase (MAPKK) homologues have failed. Here we report the characterization of a novel plasmodial protein kinase, PfPK7, whose top scores in blastp analysis belong to the MAPKK3/6 subgroup of MAPKKs. However, homology to MAPKKs is restricted to regions of the C-terminal lobe of the kinase domain, whereas the N-terminal… CONTINUE READING

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