PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.

@article{Bray2006PfCRTAT,
  title={PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.},
  author={Patrick G. Bray and Mathirut Mungthin and Ian M. Hastings and Giancarlo A Biagini and Dauda K Saidu and Viswanathan Lakshmanan and David J. Johnson and Ruth H Hughes and Paul A. Stocks and Paul M O'neill and David A. Fidock and David Charles Warhurst and Stephen A Ward},
  journal={Molecular microbiology},
  year={2006},
  volume={62 1},
  pages={238-51}
}
It is accepted that resistance of Plasmodium falciparum to chloroquine (CQ) is caused primarily by mutations in the pfcrt gene. However, a consensus has not yet been reached on the mechanism by which resistance is achieved. CQ-resistant (CQR) parasite lines accumulate less CQ than do CQ-sensitive (CQS) parasites. The CQR phenotype is complex with a component of reduced energy-dependent CQ uptake and an additional component that resembles energy-dependent CQ efflux. Here we show that the… CONTINUE READING

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