PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites

  title={PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites},
  author={Arnaud Ch{\^e}ne and Shruthi Sridhar Vembar and Lo{\"i}c Rivi{\`e}re and Jos{\'e} Juan L{\'o}pez-Rubio and Aur{\'e}lie Claes and T Nicolai Siegel and Hiroshi Sakamoto and Christine Scheidig-Benatar and Rosaura Hernandez-Rivas and Artur Scherf},
  booktitle={Nucleic acids research},
In Plasmodium falciparum, perinuclear subtelomeric chromatin conveys monoallelic expression of virulence genes. However, proteins that directly bind to chromosome ends are poorly described. Here we identify a novel DNA/RNA-binding protein family that bears homology to the archaeal protein Alba (Acetylation lowers binding affinity). We isolated three of the four PfAlba paralogs as part of a molecular complex that is associated with the P. falciparum-specific TARE6 (Telomere-Associated Repetitive… CONTINUE READING
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