Peyer's Patches Epithelium in the Rat

@article{Onori2004PeyersPE,
  title={Peyer's Patches Epithelium in the Rat},
  author={P. Onori and A. Franchitto and R. Sferra and A. Vetuschi and E. Gaudio},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={46},
  pages={1095-1104}
}
The epithelial layer covering lymphoid follicles of Peyer's patches consists of cells with a different surface morphology. Some of these cells have been described as a distinct cytotype, the so-called M cells. In order to resolve the controversy on the specific morphological and biochemical markers of M cells, structural, ultrastructural, and morphometrical study of the epithelium covering the rat Peyer's patches were performed. Peyer's patches from healthy rats were processed for light… Expand

Figures from this paper

Mucus Properties and Goblet Cell Quantification in Mouse, Rat and Human Ileal Peyer's Patches
TLDR
Transmission electron micrographs support the identification of mucus releasing goblet cells on the domes of PPs in these species, and immunostaining of FAE from mice, rats and humans with a specific antibody against the main component of intestinal mucus, the MUC2 mucin, clearly identify mucin-containing gobleT cells. Expand
Barrier Function of the Follicle-Associated Epithelium in Stress and Crohn's disease
Background The follicle-associated epithelium (FAE) is specialized in uptake and sampling of luminal antigens and bacteria. We previously showed that stress increased FAE permeability in rats. AnExpand
Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptor.
TLDR
A potential role of enterocytes in the absorption of bovine prions during oral infection through specific LRP/LR-dependent endocytosis is underscore. Expand
The Cellular Prion Protein PrPc Is Expressed in Human Enterocytes in Cell-Cell Junctional Domains*
TLDR
The results point out the signaling of cell-cell contacts as a putative role for PrPc in epithelial cells in intestinal epithelium. Expand
Immunology. Antigen-presenting cells in the gut.
TLDR
The present understanding of the possible roles of PP and LP in intestinal immunity in terms of induction, regulation, surveillance of immune responses and the antigen presenting cell types involved is reviewed. Expand
Regional Peptide Uptake Study in the Rat Intestinal Mucosa: Glatiramer Acetate as a Model Drug
TLDR
The rat colonic wall was identified to be less proteolytically active toward GA compared to the wall of the more proximal regions of the small intestine, suggesting that GA has the capacity to penetrate from the lumen into the Colonic wall. Expand
Challenges in translational research on probiotic lactobacilli: from in vitro assays to clinical trials.
TLDR
This review focuses on the immunomodulatory properties of lactobacilli and bifidobacteria in vitro and in vivo, current knowledge concerning the mechanisms in vivo and challenges in translational research on probiotics. Expand

References

SHOWING 1-10 OF 53 REFERENCES
The development of M cells in Peyer's patches is restricted to specialized dome-associated crypts.
TLDR
It is concluded that M cells represent a separate cell line that is induced in the dome-associated crypts by still unknown, probably diffusible lymphoid factors. Expand
Cytosolic distribution of villin in M cells from mouse Peyer's patches correlates with the absence of a brush border.
TLDR
The cytoplasmic distribution of villin provides a new identification criteria for M cells and reflects the reorganization of the F-actin network, which correlates with the inability of M cells to assemble a brush border. Expand
Ultrastructure and alkaline phosphatase activity of the dome epithelium of canine Peyer's patches.
TLDR
The dome epithelium of Peyer's patches from different parts of the intestine of four dogs was examined by scanning and transmission electron-microscopy and by alkaline phosphatase histochemistry on glycol-methacrylate embedded sections to allow identification of M cells at the light microscopic level. Expand
Identification of M cells and their distribution in rabbit intestinal Peyer's patches and appendix
TLDR
The co-localisation of these two phenotypic markers in both M cells and epithelial cells adjacent to crypts, which lack the typical morphology of fully developed rabbit M cells, suggests that they correspond to immature M cells which by their location appear to derive directly from undifferentiated crypt stem cells and not from mature columnar enterocytes. Expand
Differential surface characteristics of M cells from mouse intestinal Peyer's and caecal patches
SummaryThe mouse caecal patch is located near the blind end of the caecum, and consists of a group of lymphoid follicles. In common with the Peyer's patches, the follicle-associated epitheliumExpand
Immunocytochemical characterization of the follicle-associated epithelium of Peyer's patches: anti-cytokeratin 8 antibody (clone 4.1.18) as a molecular marker for rat M cells.
TLDR
The follicle-associated epithelium of Peyer's patches from the small intestine of rats was analyzed by indirect immunofluorescence and immunogold electron microscopy and the expression of intermediate filament proteins in the FAE was found to be heterogeneous. Expand
Epithelial M cells in the rabbit caecal lymphoid patch display distinctive surface characteristics
TLDR
The present data support the hypothesis that M cells arise directly from differentiation of crypt stem cells and not from the transformation of existing fully differentiated enterocytes, and suggest marked heterogeneity in the apical surface of M cells at discrete GALT sites. Expand
Epithelial cell specialization within human Peyer's patches: an ultrastructural study of intestinal lymphoid follicles.
TLDR
The newly discovered epithelial cells contain multiple vesicles that suggest a transport function, possibly for luminal antigenic material or for secretory immunoglobulin, in human intestinal mucosal cell type M cells. Expand
Immune cells associated with M cells in the follicle-associated epithelium of Peyer's patches in the rat
TLDR
It is demonstrated that the follicle-associated epithelium of rat Peyer's patches contains all the effector cells of immune responses, reinforcing the concept of immune specialization of the follicles associated epithelial cells. Expand
Structure, distribution, and origin of M cells in Peyer's patches of mouse ileum.
TLDR
It is suggested recently that M cells differentiate from absorptive cells on the follicular epithelium, but the observations here strongly suggest that many, if not all, M cells derive directly from undifferentiated crypt cells. Expand
...
1
2
3
4
5
...