Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".

@article{Lau2012PeyersPM,
  title={Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".},
  author={Wim BM de Lau and Pekka Kujala and Kerstin Schneeberger and Sabine Middendorp and Vivian S W Li and Nick Barker and Anton C. M. Martens and Frans M. A. Hofhuis and Rodney P DeKoter and Peter J Peters and Edward E. S. Nieuwenhuis and Hans Clevers},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 18},
  pages={3639-47}
}
Peyer's patches consist of domains of specialized intestinal epithelium overlying gut-associated lymphoid tissue (GALT). Luminal antigens reach the GALT by translocation through epithelial gatekeeper cells, the so-called M cells. We recently demonstrated that all epithelial cells required for the digestive functions of the intestine are generated from Lgr5-expressing stem cells. Here, we show that M cells also derive from these crypt-based Lgr5 stem cells. The Ets family transcription factor… CONTINUE READING
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