Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p.

@article{Otzen2012Pex19pCT,
  title={Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p.},
  author={Marleen Otzen and Robert Ruckt{\"a}schel and Sven Thoms and Kerstin Emmrich and Arjen M. Krikken and Ralf Erdmann and Ida J van der Klei},
  journal={Traffic},
  year={2012},
  volume={13 7},
  pages={947-59}
}
During budding of yeast cells peroxisomes are distributed over mother cell and bud, a process that involves the myosin motor protein Myo2p and the peroxisomal membrane protein Inp2p. Here, we show that Pex19p, a peroxin implicated in targeting and complex formation of peroxisomal membrane proteins, also plays a role in peroxisome partitioning. Binding studies revealed that Pex19p interacts with the cargo-binding domain of Myo2p. We identified mutations in Myo2p that specifically reduced binding… CONTINUE READING

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