Peutz–Jeghers LKB1 mutants fail to activate GSK-3β, preventing it from inhibiting Wnt signaling

@article{LinMarq2005PeutzJeghersLM,
  title={Peutz–Jeghers LKB1 mutants fail to activate GSK-3β, preventing it from inhibiting Wnt signaling},
  author={Nathalie Lin-Marq and Christelle Borel and Stylianos E. Antonarakis},
  journal={Molecular Genetics and Genomics},
  year={2005},
  volume={273},
  pages={184-196}
}
Peutz–Jeghers syndrome (PJS) is caused by germline mutations in the LKB1 gene, which encodes a serine-threonine kinase that regulates cell proliferation and polarity. This autosomal dominant disorder is characterized by mucocutaneous melanin pigmentation, multiple gastrointestinal hamartomatous polyposis and an increased risk of developing various neoplasms. To understand the molecular pathogenesis of PJS phenotypes, we used microarrays to analyze gene expression profiles in proliferating HeLa… CONTINUE READING

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The Wnts

  • JR Miller
  • Genome Biol
  • 2002
Highly Influential
4 Excerpts

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