Peter Paul Rickham Prize--1998. Neutrophil dysfunction the cellular mechanism of impaired immunity during total parenteral nutrition in infancy.

@article{Okada1999PeterPR,
  title={Peter Paul Rickham Prize--1998. Neutrophil dysfunction the cellular mechanism of impaired immunity during total parenteral nutrition in infancy.},
  author={Yasuhiro Okada and Nigel Klein and Agostino Pierro},
  journal={Journal of pediatric surgery},
  year={1999},
  volume={34 2},
  pages={242-5}
}
BACKGROUND Studies have shown that total parenteral nutrition (TPN) in infancy is associated with impaired immunity. The causes of this acquired immunodeficiency are poorly understood. Bacterial infection is a major complication of TPN suggesting neutrophils may be affected by this feeding modality. PURPOSE The aim of this study was to test the hypothesis that TPN-related impaired bactericidal activity is related to impairment of neutrophil function, particularly intracellular killing… CONTINUE READING