Analyses prospectives de mortalité : approches actuarielle et biomédicale
- Political Science
La duree de vie humaine augmente dans le monde depuis quelques siecles. Cette augmentation a ete plus importante que ne le predisaient les specialistes qui ont enonce des limites. Malgre les…
NIA’s intervention testing program at 10 years of age
The development of the Intervention Testing Program and some of the early success achieved during its first 10 years (2004–2014) of operation are described.
Anti-Inflamm-Ageing and/or Anti-Age-Related Disease Emerging Treatments: A Historical Alchemy or Revolutionary Effective Procedures?
- Medicine, BiologyMediators of inflammation
New emerging molecules, drugs, and procedures will be described, by evidencing potential benefits and limitations of antiageing interventions in humans and resulting in benefits for their health in old ages.
m-TOR Inhibitors in the Current Practice
- Medicine, Biology
In this review article, the clinical indications, advantage and disadvantage of m-TOR inhibitors over other immunosuppressant’s medications and their clinical indications inside and outside the transplant field are tried.
Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging
- BiologyFront. Physiol.
The importance of the Sirtuin, mTOR and Insulin/Insulin like growth factor-1 pathways as well as the significant role played by epigenetics in the dietary regulation of NSCs are highlighted and the need for further research to exploit nutrition as a mode of intervention to regulate N SCs aging is highlighted.
Experimental Transmission of Alzheimer's Disease Endophenotypes to Murine and Primate Models
- Biology, Psychology
The results support the “prion-like” hypothesis of AD and provide further arguments for a dichotomy between the toxicity of deposited and soluble assemblies of Aβ or Tau proteins.
The Biology of Aging
- Medicine, BiologyVeterinary pathology
Key challenges moving forward will be to assess the extent to which these and other interventions improve healthy longevity and increase life span in mice and to develop practical strategies for extending this work to the clinic.
Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.
- Biology, MedicineThe journals of gerontology. Series A, Biological sciences and medical sciences
How the use of alternative rapamycin treatment regimens or Rapamycin analogs has the potential to mitigate the deleterious side effects of rap amycin treatment by more specifically targeting mTORC1 is discussed.