Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.

@article{Karami2013PesticideEA,
  title={Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.},
  author={Sara Karami and Gabriella Andreotti and Stella Koutros and Kathryn Hughes Barry and Lee E. Moore and Summer S Han and Jane A. Hoppin and Dale P Sandler and Jay H. Lubin and Laurie A. Burdette and Jeffrey Yuenger and Meredith Yeager and Laura E. Beane Freeman and Aaron Blair and Michael C. R. Alavanja},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2013},
  volume={22 9},
  pages={1557-66}
}
BACKGROUND Vitamin D and its metabolites are believed to impede carcinogenesis by stimulating cell differentiation, inhibiting cell proliferation, and inducing apoptosis. Certain pesticides have been shown to deregulate vitamin D's anticarcinogenic properties. We hypothesize that certain pesticides may be linked to prostate cancer via an interaction with vitamin D genetic variants. METHODS We evaluated interactions between 41 pesticides and 152 single-nucleotide polymorphisms (SNP) in nine… CONTINUE READING
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