Pesticide Resistance via Transposition-Mediated Adaptive Gene Truncation in Drosophila

@article{Aminetzach2005PesticideRV,
  title={Pesticide Resistance via Transposition-Mediated Adaptive Gene Truncation in Drosophila},
  author={Yael T. Aminetzach and J. M. Macpherson and D. Petrov},
  journal={Science},
  year={2005},
  volume={309},
  pages={764 - 767}
}
To study adaptation, it is essential to identify multiple adaptive mutations and to characterize their molecular, phenotypic, selective, and ecological consequences. Here we describe a genomic screen for adaptive insertions of transposable elements in Drosophila. Using a pilot application of this screen, we have identified an adaptive transposable element insertion, which truncates a gene and apparently generates a functional protein in the process. The insertion of this transposable element… Expand
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