Pesticide Exposures and Developmental Outcomes: The Epidemiological Evidence

@article{Weselak2007PesticideEA,
  title={Pesticide Exposures and Developmental Outcomes: The Epidemiological Evidence},
  author={M. Weselak and T. Arbuckle and W. Foster},
  journal={Journal of Toxicology and Environmental Health, Part B},
  year={2007},
  volume={10},
  pages={41 - 80}
}
Since the advent of DDT as an insecticide in the late 1930s, billions of kilograms of pesticide active ingredient have been sold in North America and around the world. In recent years, there has been a heightened public awareness of pesticides and child health and a number of epidemiologic studies linked pre- and postnatal exposures to pesticides to a number of adverse developmental outcomes, including fetal death, intrauterine growth restriction, preterm birth, and birth defects. Given this… Expand
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Citation Type

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A trend towards a positive association between environmental or occupational exposure to some pesticides and some CAs was detected and this association remains to be substantiated, but main limitations of the review include inadequate exposure assessment and limited sample size. Expand
Pesticide Exposure and Neurodevelopmental Outcomes: Review of the Epidemiologic and Animal Studies
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Although the published animal studies may have characterized potential neurodevelopmental outcomes using endpoints not required by guideline studies, the effects were generally observed at or above effect levels measured in repeated-dose toxicology studies submitted to the U.S. Environmental Protection Agency (EPA). Expand
Living near agricultural pesticide applications and the risk of adverse reproductive outcomes: a review of the literature.
TLDR
The evidence suggested an association for congenital malformations, but because of methodological limitations, such as poor exposure measurement and potentially inadequate control of confounding, a firm conclusion remains beyond reach. Expand
Developmental and Reproductive Toxicology of Pesticides
TLDR
There is greater concordance between laboratory animal models and humans for adverse effects on fertility than in the area of developmental effects in animals, however, developmental toxicity in animals does not translate to the same kind of developmental defect in humans. Expand
Epidemiologic Evidence of Relationships Between Reproductive and Child Health Outcomes and Environmental Chemical Contaminants
This review summarizes the level of epidemiologic evidence for relationships between prenatal and/or early life exposure to environmental chemical contaminants and fetal, child, and adult health.… Expand
Potential Effects of Chlorpyrifos on Fetal Growth Outcomes: Implications for Risk Assessment
TLDR
The animal data indicate that developmental effects occur at doses that produce substantial maternal toxicity and red blood cell (RBC) acetylcholinesterase (AChE) inhibition, which is a more sensitive endpoint for risk assessment than somatic developmental effects reviewed in this article. Expand
Prenatal exposure to pesticides and risk for holoprosencephaly: a case-control study
TLDR
Observed findings are consistent with experimental evidence and suggest that exposure to personal, household, and agricultural pesticides during pregnancy may increase risk for holoprosencephaly. Expand
Evaluation of Epidemiology and Animal Data for Risk Assessment: Chlorpyrifos Developmental Neurobehavioral Outcomes
TLDR
There was insufficient evidence that human developmental exposures to CPF produce adverse neurobehavioral effects in infants and children across different cohort studies that may be relevant toCPF exposure. Expand
Atrazine and Pregnancy Outcomes: A Systematic Review of Epidemiologic Evidence
TLDR
Considering the poor quality of the data and the lack of robust findings across studies, conclusions about a causal link between ATR and adverse pregnancy outcomes are not warranted. Expand
Pesticide Exposure in Children
TLDR
Prospective cohort studies link early-life exposure to organophosphates and organochlorine pesticides with adverse effects on neurodevelopment and behavior, and among the findings associated with increased pesticide levels are poorer mental development by using the Bayley index and increased scores on measures assessing pervasive developmental disorder, inattention, and attention-deficit/hyperactivity disorder. Expand
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