Pesticide Exposures and Developmental Outcomes: The Epidemiological Evidence
@article{Weselak2007PesticideEA, title={Pesticide Exposures and Developmental Outcomes: The Epidemiological Evidence}, author={Mandy Weselak and Tye Elaine Arbuckle and Warren G. Foster}, journal={Journal of Toxicology and Environmental Health, Part B}, year={2007}, volume={10}, pages={41 - 80} }
Since the advent of DDT as an insecticide in the late 1930s, billions of kilograms of pesticide active ingredient have been sold in North America and around the world. In recent years, there has been a heightened public awareness of pesticides and child health and a number of epidemiologic studies linked pre- and postnatal exposures to pesticides to a number of adverse developmental outcomes, including fetal death, intrauterine growth restriction, preterm birth, and birth defects. Given this…
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References
SHOWING 1-10 OF 184 REFERENCES
Pesticide exposures and fetal death: a review of the epidemiologic literature.
- PsychologyCritical reviews in toxicology
- 1998
There is a clear need for epidemiologic research that focuses on specific pesticide products or chemical families, with improved exposure assessment, and the potential role of solvents in developmental toxicity associated with pesticide use by both males and females should also be considered.
In utero pesticide exposure, maternal paraoxonase activity, and head circumference.
- BiologyEnvironmental health perspectives
- 2004
The effects of pesticide exposure on birth weight, length, head circumference, and gestational age among 404 births between May 1998 and May 2002 are evaluated and chlorpyrifos may have a detrimental effect on fetal neurodevelopment among mothers who exhibit low PON1 activity.
Use of biomarkers to indicate exposure of children to organophosphate pesticides: implications for a longitudinal study of children's environmental health.
- MedicineEnvironmental health perspectives
- 2003
The advantages and disadvantages of the currently available OP exposure monitoring methods (cholinesterase inhibition inBlood, pesticides in blood, metabolites in urine and alternative matrices); study design issues for a large, long-term study of children's environmental health; and current research and future research needs are discussed.
Exposures of children to organophosphate pesticides and their potential adverse health effects.
- BiologyEnvironmental health perspectives
- 1999
A Center for the Health Assessment of Mothers and Children of Salinas, or CHAMACOS in Monterey County, California, will assess (italic) in utero and postnatal OP pesticide exposure and the relationship of exposure to neurodevelopment, growth, and symptoms of respiratory illness in children.
Occupational exposure to pesticides and congenital malformations: a review of mechanisms, methods, and results.
- MedicineAmerican journal of industrial medicine
- 1998
There is inadequate evidence for either establishing a relationship between pesticides exposure in human beings and birth defects or for rejecting it, and some of the key elements for future research are presented.
Association of in Utero Organophosphate Pesticide Exposure and Fetal Growth and Length of Gestation in an Agricultural Population
- BiologyEnvironmental health perspectives
- 2004
These associations with gestational age may be biologically plausible given that organophosphate pesticides depress cholinesterase and acetylcholine stimulates contraction of the uterus, and despite these observed associations, the rate of preterm delivery in this population was lower than in a U.S. reference population.
An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population.
- Environmental ScienceEnvironmental health perspectives
- 2001
This study shows that timing of exposure and restricting analyses to more homogeneous endpoints are important in characterizing the reproductive toxicity of pesticides.
Pesticides and congenital malformations--how many studies will it take to reach a conclusion?
- MedicineScandinavian journal of work, environment & health
- 1998
A recent review identified 34 epidemiologic studies on occupational exposure to pesticides in relation to congenital malformations published after 1980 with no conclusions to be drawn even though some of the studies were not small in size and a few used fairly detailed methods for exposure assessment.
Relation between pesticide exposure and intrauterine growth retardation.
- MedicineChemosphere
- 2004
Reduced birthweight and length in the offspring of females exposed to PCDFs, PCP, and lindane.
- MedicineEnvironmental health perspectives
- 1995
Investigating a broad range of adverse health outcomes and their potential association to wood preservative used in daycare centers found a significantly reduced but weight and length differences in exposed pregnancies, even after restricting the data to independent pregnancies and pregnancies for which data could be validated from the mother's health cards.