Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation.

@article{LerchGaggl2002PescadilloIE,
  title={Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation.},
  author={Alexandra F. Lerch-Gaggl and Jamil Haque and Jixuan Li and Gang Ning and Paula Traktman and S A Duncan},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 47},
  pages={45347-55}
}
Mutation of the zebrafish pescadillo gene blocks expansion of a number of tissues in the developing embryo, suggesting roles for its gene product in controlling cell proliferation. We report that levels of the pescadillo protein increase in rodent hepatocytes as they enter the cell cycle. Pescadillo protein localizes to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of… CONTINUE READING

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